Structure of PDB 8rev Chain A Binding Site BS01

Receptor Information
>8rev Chain A (length=709) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEFMIDDLPVLFPYPRIYPEQYAYMCDLKKTLDAGGNCVLEMPSGTGKTI
TLLSLIVAYQQHYAEHRKLIYCSRTMSEIEKALVELKALMKFRAERLGYV
EEFRGLGLTSRKNLCLHPSVKREKSGTIVDARCRSLTAGFVKEKKQRGED
VDVCIYHDNLDLLEPHNLIPNGIWTLDNLLKYGEEHKQCPYFTARRMLQY
CNVVIYSYHYLLDPKIAERVSRDLSSDSIVVFDEAHNIDNVCIEALSTDI
TEESLRRATRGAQNLENRINEMKEGNIRRAEHFVAFLRRFIEYLKTRMKV
RQVISETPPSFLAHLKEYTFIEKKPLRWCAERLTSLVRTLELTNIEDYHA
LQEVATFATLVATYEKGFLLILEPYESDTAEVPNPVLHFCCLDAAIAIKP
VFDKFRNVIITSGTISPLEMYPKMLNFTTVVQESYSMTLARRSFLPLIVT
RGSDQASISTGFQVRNEPSVVRNYGNLLTEFAKITPDGMVVFFPSYLYME
SIISMWQGMGILDEVWKYKLILVETPDAQETSLALETYRTACCNGRGAVL
LCVARGKVSEGIDFDHQYGRTVLCIGVPFQYTESRILKARLEFLRETYRI
RENDFLSFDAMRHAAQCLGRVLRGKDDYGLMVLADRRFQKKRNQLPKWIA
QALLDADTNLSTDMAVSSARRFLKTMAQPFKAKDQEGISTWSLEDLKRHQ
QKMDEERMK
Ligand information
Receptor-Ligand Complex Structure
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PDB8rev XPD stalled on cross-linked DNA provides insight into damage verification
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T75 T109 S110 R111 R134 Y191 R195 H209 Y210 K215 I216 R219 E244 R383 G506 F507 P539 S540 Y541 V598 R600 G601 K602 F624 Q625 Y626 T627 E628 R646 N648 R682
Binding residue
(residue number reindexed from 1)		T75 T109 S110 R111 R134 Y191 R195 H209 Y210 K215 I216 R219 E244 R338 G461 F462 P494 S495 Y496 V553 R555 G556 K557 F579 Q580 Y581 T582 E583 R601 N603 R637
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0006366 transcription by RNA polymerase II
GO:0006974 DNA damage response
GO:0032508 DNA duplex unwinding
GO:0045951 positive regulation of mitotic recombination
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rev, PDBe:8rev, PDBj:8rev
PDBsum8rev
PubMed38806694
UniProtG0RZH0

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