Structure of PDB 8rbx Chain A Binding Site BS01

Receptor Information
>8rbx Chain A (length=1391) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKKNICGGCGRYQ
PRIRRSGLELYAEWKKKILLSPERVHEIFKRISDEECFVLGMEPRYARPE
WMIVTVLPVPPLSVRPAVRNQDDLTHKLADIVKINNQLRRNEQNGAAAHV
IAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRG
NLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRL
QELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCD
GDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMN
LHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRD
VFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINC
IRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSL
VHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDI
QNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKT
GSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGF
KHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAV
KTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVE
FQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNEL
EREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPS
DLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSR
RMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQM
VTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTL
RKVTANTAIYYDPNPQSTVVAEDQEWVNVISPWLLRVELDRKHMTDRKLT
MEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNDDDVFLRCIESNML
TDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSL
MRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYV
NYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAA
AHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rbx Structural basis of Integrator-dependent RNA polymerase II termination
Resolution4.1 Å
Binding residue
(original residue number in PDB)		R67 R430 F431 Q461 D497 D499
Binding residue
(residue number reindexed from 1)		R57 R378 F379 Q409 D445 D447
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rbx, PDBe:8rbx, PDBj:8rbx
PDBsum8rbx
PubMed38570683
UniProtA0A7M4DUC2

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