Structure of PDB 8r6w Chain A Binding Site BS01

Receptor Information

>8r6w Chain A (length=1974) Species: 992210 (SFTS virus AH12)

MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLSKTTDRRLSEVFP
ITHDGSDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYR
DPISRRVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANE
IYTKARSEELEAISRALSFFSLFEPNIERVEGTFPNSEIKMLEQFLSTPA
DVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEINRCEAIDKTQDL
LAGLHARSNKQTSLNRGTVKLPPWLPKPSSESIDIKTDSGFGSLMDHGAY
GELWAKCLLDVSLGNVEGVVSDPAKELDIAISDDPITYRRFKPALSSSAR
QEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLDVEDIGDFLTFNNLLT
DSRYGDESIQRAVSILLEKASAMQDTELTHALNDSFKRNLSSNVVQWSLW
VSCLAQELASALKQHCRAGEFIIKKLKFWPIYVIIKPTKSSSHIFYSLGI
RKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCKLTNLVNLPCTMLNSI
AFWREKLGVAPWLVRKPCSELREQVGLTFLISLEDKSKTEEIITLTRYTQ
MEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRKHLDCMVRIASQPFSL
IPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYYKNKEESTELNALGEM
YKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSFLRAACSSLEREIAQR
HGRQWKQNLEERVLREIGTKNILDLASMKATSNFSKDWELYSEVQTKEYH
RSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGCMRICLFKKNQHGGLR
EIYVMDANARLVQFGVETMARCVCELSPHETVANPRLKNSIIENHGLKSA
RSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPAKFHRFIWAAISM
FRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHGNRDVSWMDKGRT
YIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKEGYMGESISGVVD
VIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKFLNPLFGIYSSEK
STVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISETEALASRQEDYSN
LLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLFGTFMGMLISDPD
PALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAYYFNEIQGKTKGD
EDYRALDATSGGTLSHSVMVYWGDRKKYQALLNRMGLPEDWVEQIDENPG
VLYRRAANKKELLLKLAEKVHSPGVTSSLSKGHVVPRVVAAGVYLLSRHC
FRFSTQKASLIKLLMMSSISAMKHGGSLNPNQERMLFPQAQEYDRVCTLL
EEVEHLTGKFVVRERNIVRSRIDLFQEPVDLRCKAEDLVSEVWFGLKRTK
LGPRLLKEEWDKLRASFAWLSTDPSETLRDGPFLSHVQFRNFIAHVDAKS
RSVRLLGAPVTTISQVVRMNFFPGFSLEAEESISILKHVLFMVLNGPYTE
EYKLEMIIEAFSTLVIPQPSEVIRKSRTMTLCLLSNYLSSRGGSILDQIE
RAQSGTLGGFSKPQKTFVRPGGGVGYKGKGVWTGVMEDTHVQILIDGDGT
SNWLEEIRLSSDARLYDVIESIRRLCDDLGINNRVASAYRGHCMVRLSGF
KIKPASRTDGCPVRIMNPDEVKMRVRGDILNLSVTIQEGRVMNILSYRPR
DTDISESAAAYLWSNRDLFSFGKKEPSCSWICLKTLDNWAWSHASVLLAN
DRKTQGIDNRAMGNIFRDCLEGSLRKQGLMRSKLIAVELSEGSLDIESIF
DGAPILWSAEVEEFGEGVVAVSYSSKYYHLTLMDQAAITMCAIMGKEGCR
GLLTEKRCMAAIREQVRPFLIFLQ

Ligand information

>8r6w Chain G (length=4)

acac

....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8r6w Structural snapshots of phenuivirus cap-snatching and transcription
• Resolution: 3.35 Å
• Binding residue (original residue number in PDB): Q915 R920 W989 Q1080 S1125 D1126 R1197 Q1204 Q1224
• Binding residue (residue number reindexed from 1): Q895 R900 W969 Q1060 S1105 D1106 R1177 Q1184 Q1204

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0016740 transferase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039694 viral RNA genome replication

Cellular Component

• GO:0044165 host cell endoplasmic reticulum
• GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
• GO:0044177 host cell Golgi apparatus
• GO:0044423 virion component

External links

• PDB: RCSB:8r6w, PDBe:8r6w, PDBj:8r6w
• PDBsum: 8r6w
• PubMed: 38709882
• UniProt: I0DF35|L_SFTS RNA-directed RNA polymerase L