Structure of PDB 8r65 Chain A Binding Site BS01

Receptor Information
>8r65 Chain A (length=716) Species: 88776 (Influenza A virus (A/Brevig Mission/1/1918(H1N1))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSD
FHFINERGESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGA
EKPKFLPALYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSF
TGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEET
IEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMS
KEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLAWKQVLAELQDIEN
EEKIPKTKNMKKTSQLKWALGENMAPEKVDFDDCKDVSDLKQYDSDEPEL
RSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEV
SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL
YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL
RSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLY
ASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV
LLNASWFNSFLTHALR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8r65 1918 H1N1 Viral polymerase heterotrimer in complex with 4 repeat serine-5 phosphorylated PolII peptide with ordered PB2 C-terminal domains
Resolution4.23 Å
Binding residue
(original residue number in PDB)		H326 K328 G371 E372 N373 M374 A375 Y393 E397 H510 R512 V517 K539 R566 N568 G569 K574 P653
Binding residue
(residue number reindexed from 1)		H326 K328 G371 E372 N373 M374 A375 Y393 E397 H510 R512 V517 K539 R566 N568 G569 K574 P653
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r65, PDBe:8r65, PDBj:8r65
PDBsum8r65
PubMed
UniProtQ3HM39|PA_I18A0 Polymerase acidic protein (Gene Name=PA)

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