Structure of PDB 8qwk Chain A Binding Site BS01

Receptor Information
>8qwk Chain A (length=186) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVPSQKTYQGSYGFRLGFLVTCTCSPALNKLFCQLAKTCPVQLWVDSTPP
PGTRVRAMAIYKQSQHMTEVVRRCPHHERCDGLAPPQHLIRVEGNLRAEY
LDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCYSSCMGGMNRRPILTII
TLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8qwk Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qwk Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Resolution1.69 Å
Binding residue
(original residue number in PDB)		C176 H179 C242
Binding residue
(residue number reindexed from 1)		C74 H77 C137
Annotation score4
External links
PDB RCSB:8qwk, PDBe:8qwk, PDBj:8qwk
PDBsum8qwk
PubMed38862470
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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