Structure of PDB 8qqi Chain A Binding Site BS01

Receptor Information

>8qqi Chain A (length=517) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGN
DWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQG
NFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPD
VMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEG
LMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRE
TIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEV
KRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRH
RREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAK
TALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQA
ILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELE
LVREQFGDKRRTEITAN

Ligand information

>8qqi Chain E (length=26) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

atcaggcataaaatcacccgcacaga

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	8qqi Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	V44 H78 H80 R91 I174
Binding residue (residue number reindexed from 1)	V37 H71 H73 R84 I167

External links

PDB	RCSB:8qqi, PDBe:8qqi, PDBj:8qqi
PDBsum	8qqi
PubMed	38898213
UniProt	P0AES4\|GYRA_ECOLI DNA gyrase subunit A (Gene Name=gyrA)

[Back to BioLiP]