Structure of PDB 8qkg Chain A Binding Site BS01

Receptor Information
>8qkg Chain A (length=332) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YKFNDEYRNLQWGLDLARLDETQDLINANRVSVTKICVIDSGIDYNHPDL
RNNIDVNVKELHGRKGVDDDSNGVVDDVYGANFVSNSGDPMDDNYHGTHV
SGIISAVGNNGIGIVGVDGHSKLVICKALDQHKLGRLGDMFKCIDYCISR
QAHMISGSFSFDEYSNIFSASVEHLRSLGILFFVSASNCAAKCDLAVNHR
YPPILSKTHNNVIAVANLKRDLDESYSLSVNSFYSNIYCQLAAPGTNIYS
TTPMNNYRKLNGTSMASPHVAAIASIVRSINPNLTYLQIVEILRNAIVKL
PSLTERVSWGGYVDILRAVNLAIDSKAAPYIK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8qkg Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1
Resolution1.538 Å
Binding residue
(original residue number in PDB)		Y371 H372 L405 K409 G411 S434 F435 S436 N464 N546 G547 T548 S549
Binding residue
(residue number reindexed from 1)		Y95 H96 L129 K133 G135 S158 F159 S160 N188 N261 G262 T263 S264
Enzymatic activity
Enzyme Commision number 3.4.21.62: subtilisin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8qkg, PDBe:8qkg, PDBj:8qkg
PDBsum8qkg
PubMed38503166
UniProtE6Y8B9

[Back to BioLiP]