Structure of PDB 8qhp Chain A Binding Site BS01

Receptor Information

>8qhp Chain A (length=410) Species: 186497 (Pyrococcus furiosus DSM 3638)

GGLKVYNTLTKQKEEFKPLREGEVKMYVCGPTVYDYPHLGHARTYIAFDV
IRRYLEHKGYTVLMVMNFTDIDDKIIKRARETGEDPKELAERFIKIFLED
MEALKVKPADIYPRVTDHIDDIIEFIGKLKEKGYAYEGSDGIYFEVKKFP
EYGKLSGVKIEDLQGKKNPEDFALWKKAKPGEPKWDSPWGEGRPGWHIEC
SVMSSKYLGESFDIHGGGNDLIFPHHENEIAQSEACFGHEWVKYWLHTGF
VMVKGEKMSKSLGNFVTIRELLKRYEPEVIRFFVLQKHYRSPLEYTEEGL
QHAKNNLQRLYNTLENIRVALRNAEISYTWGELEFKTYEIIREGKRKFYE
AMDDDFNTAEALKAVFEVANAINKYLTEANKPKESILRKALEFFKIVSEV
FGVFEDYFRE

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 8qhp Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8qhp An atlas of protein homo-oligomerization across domains of life
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): C28 C208 H233 E237
• Binding residue (residue number reindexed from 1): C29 C200 H225 E229
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.1.1.16: cysteine--tRNA ligase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004812 aminoacyl-tRNA ligase activity
• GO:0004817 cysteine-tRNA ligase activity
• GO:0005524 ATP binding
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation
• GO:0006418 tRNA aminoacylation for protein translation
• GO:0006423 cysteinyl-tRNA aminoacylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8qhp, PDBe:8qhp, PDBj:8qhp
• PDBsum: 8qhp
• PubMed: 38325366
• UniProt: Q8U227|SYC_PYRFU Cysteine--tRNA ligase (Gene Name=cysS)