Structure of PDB 8qh3 Chain A Binding Site BS01

Receptor Information
>8qh3 Chain A (length=1310) Species: 11602 (Hantaan virus 76-118) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YIPDYKGMEPIGANIEDLVDYSKDWLSRARNFSFFEVKGTAVFECFNSNE
ANHCQRYPMSRKPRNFLLIQCSLITSYKPATTLSDQIDSRRACSYILNLI
PDTPASYLIHDMAYRYINLTREDMINYYAPRIQFKQTQNVREPGTFKLTS
SMLRAESKAMLDLLNNQIESLNIASHIVQSESVSLITKILSDLELNIVLD
KFFQNETQKYLIDVLKKTTAWHIGHLIRDITESLIAHSGLKRSKYWSLHS
YNNGNVILFILPSKSLEVAGSFIRFITVFRIGPGLVDKDNLDTILIDGDS
QWGVSKVMSIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQYAIR
SVFANHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGFPSLIEKLFERPF
KSSLEVYIYYNIKSLLVALAQNVYPSFMSRIVYKHYRSLISEVTTCFFLF
EKGLHGNMNEEAKIHLETVEWALKFREKEEKYGESLVENGYMMWELRANA
ELAEQQLYCQDAIELAAIELNKVLATKSSVVANSILSKNWEEPYFSQTRN
ISLKGMSGQVQEDGHLSSSVTIIEAIRYLSNSRHNPSLLKLYEETREQKA
MARIVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAIAKNISEEYISYG
GEKKILAIQGALEKALRWASGESFIELSNHKFIRMKRKLMYVSADATKWS
PGDNSAKFRRFTSMLHNGLPNNKLKNCVIDALKQVYKTDFFMSRKLRNYI
DSMESLDPHIKQFLDFFPDGHHGEVKGNWLQGNLNKCSSLFGVAMSLLFK
QVWTNLFPELDCFFEFAHHSDDALFIYGYLEPVDDGTDWFLFVSQQIQAG
HLHWFSVNTEMWKSMFNLHEHILLLGSIKISPKKTTVSPTNAEFLSTFFE
GCAVSIPFVKILLGSLSDLPGLGYFDDLAAAQSRCVKALDLGASPQVAQL
AVALCTSKVERLYGTAPGMVNHPAAYLQVKHTDTPIPLGGNGAMSIMELA
TAGIGMSDKNLLKRALLGYSHKRQKSMLYILGLFKFLMKLSDETFQHERL
GQFSFIGKVQWKIFTPKSEFEFADMYTSKFLELWSSQHVTYDYIIPKGRD
NLLIYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCRLDGEWVTFR
EVLAAANSFAENYSATSQDMDLFQTLTSCTFSKEYAWKDFLNGIHCDVIP
TKQVQRAKVARTFTSIPAVIGYKFAVTVEEMSDVLDTAKFPDSLSVDLKT
MKDGVYRELGLDISLPDVMKRIAPMLYKRVVIVQGNVEGTAEAICRYWLK
SMSLVKTIRV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qh3 Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		Y282 L389 Q401 I402 G522 F524 K558 S561 R566 K616 M617 K618 K653 G733 N736 A739 Y1026 I1027 M1030 S1032 D1034 I1037 F1040
Binding residue
(residue number reindexed from 1)		Y57 L164 Q167 I168 G270 F272 K306 S309 R314 K364 M365 K366 K401 G456 N459 A462 Y749 I750 M753 S755 D757 I760 F763
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004519 endonuclease activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044220 host cell perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qh3, PDBe:8qh3, PDBj:8qh3
PDBsum8qh3
PubMed38480734
UniProtP23456|L_HANTV RNA-directed RNA polymerase L (Gene Name=L)

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