Structure of PDB 8q9t Chain A Binding Site BS01

Receptor Information
>8q9t Chain A (length=1075) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELYQSLKEEDRITKLDANDIIKDRFLRPSNALPWSLLDMVQDVDYKELLK
VPDPINRTSYQFKRTGLEGKISGYKEEVDLKVANANASNSLSITRSINHN
QNSVRGSTAQLPFTPGGIPSTMANATKLLHKDGQGLFDIPEGMNRGIKPM
LKQLNEIDNADDAEIDELLPEWAHVVFDELIPNPARSWPFELDTFQKEAV
YHLEQGDSVFVAAHTSAGKTVVAEYAIAMAHRNMTKTIYTSPIKALSNQK
FRDFKETFDDVNIGLITGDVQINPDANCLIMTTEILRSMLYRGADLIRDV
EFVIFDEVHYVNDQDRGVVWEEVIIMLPQHVKFILLSATVPNTYEFANWI
GRTKQKNIYVISTPKRPVPLEINIWKKELIPVINQNSEFLEANFRKHKEI
SKKTWPEIVNYLRKRELLPMVVFVFSKKRCEEYADWLEGINFCNNKEKSQ
IHMFIEKSITRLKKEDRDLPQILKTRSLLERGIAVHHGGLLPIVKELIEI
LFSKGFIKVLFATETFAMGLNLPTRTVIFSSIRKHDNGLRELTPGEFTQM
AGRAGRRGLDSTGTVIVMAYSPLSIATFKEVTMGVPTRLQSQFRLTYNMI
LNLLRIEALRVEEMIKYSFSENAKETLQPEHEKQIKVLQEELQTIEYKSC
EICDNDIEKFLELMLAYKEATVNLMQEMVKSPSILHILKEGRLVAFRDPN
DCLKLGFVFKVSLKDAVCVIMTFTKPYKLPNGEPNHLIYFPKADGYRRRN
FPKFQKTDFYMEEVPVTAIEVITKRKFAAPLGKVIKKDVAALNEFNAETN
NILDGKTLKEANIEKQGLKIHQILLDRTNIRDEIFKLKSIKCPNLSQHIV
PKFKAHVIKKKIEELYHLMSDQNLSLLPDYEKRLAVLKDTEFIDQNHNVL
LKGRVACEINSGYELVLTELILDNFLGSFEPEEIVALLSVFVYEGKTREE
EPPIVTPRLAKGKQRIEEIYKKMLCVFNTHQIPLTQDEAEFLDRKRFAMM
NVVYEWARGLSFKEIMEMSPEAEGTVVRVITWLDEICREVKTASIIIGNS
TLHMKMSRAQELIKRDIVFAASLYL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8q9t Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Resolution2.84 Å
Binding residue
(original residue number in PDB)		Q452 S635 K636 T722 H744 W1244
Binding residue
(residue number reindexed from 1)		Q314 S426 K427 T513 H535 W1032
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0006417 regulation of translation
GO:0051607 defense response to virus
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay
Cellular Component
GO:0005737 cytoplasm
GO:0055087 Ski complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q9t, PDBe:8q9t, PDBj:8q9t
PDBsum8q9t
PubMed37879335
UniProtP35207|SKI2_YEAST Antiviral helicase SKI2 (Gene Name=SKI2)

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