Structure of PDB 8q8k Chain A Binding Site BS01

Receptor Information
>8q8k Chain A (length=423) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYFS
Ligand information
>8q8k Chain C (length=12) Species: 423446 (KI polyomavirus Stockholm 60) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KRSAQATPPKKK
Receptor-Ligand Complex Structure
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PDB8q8k A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		W142 N146 A148 S149 G150 T151 T155 W184 N188 G191 D192 W231 R238 W273 V321 T322 G323 W357 N361 E396 W399
Binding residue
(residue number reindexed from 1)		W68 N72 A74 S75 G76 T77 T81 W110 N114 G117 D118 W157 R164 W199 V247 T248 G249 W283 N287 E322 W325
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q8k, PDBe:8q8k, PDBj:8q8k
PDBsum8q8k
PubMed38108201
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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