Structure of PDB 8q7v Chain A Binding Site BS01

Receptor Information
>8q7v Chain A (length=1645) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSEEKLQEKARKWQQLQAKRYAEEDMPPEHVRKIIRDHKRVYLGALKYMP
HAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGS
MWIMMRREKRDRFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPE
EDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTD
LVDDNYFYLFDLKAFFTSKALNMAIPGGPKFEPLDEDWNEFNDINKIIIR
QPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPL
INPISHREPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPF
NLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKLLKYYVLNALKH
RPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRK
NLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREVLRLTKLVVDSH
VQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHL
IYYRFNTGPVGKGPGCGFWAAGWRVWLFFMRGITPLLERWLGNLLASHFD
LELRAAVMHDILDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLP
TPIENMILRYVKAKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRL
YLKAEQERQHNYLKDGPYITAEEAVAVYTTTVHWLESRRFSPIPFPPLSY
KHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIK
RHLLTQRAFKEVGIEFMDLYSHLVPVYDVEPLEKITDAYLDQYLWYEADK
RRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWETSEGECNVMLESRFE
KMYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIR
GLQFASFIVQYYGLVMDLLVLGLHRASEMAGPPQMPNDFLSFQDIATEAA
HPIRLFCRYIDRIHIFFRFTADEARDLIQRYLTEHPDPNNENIVGYNNKK
CWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTVQWENSFVSVYSKDN
PNLLFNMCGFECRILPKCRTSYEEFTHKDGVWNLQNEVTKERTAQCFLRV
DDESMQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQ
ELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGH
VLIPQSDLRWSKQTDVGITHFRSQLIPNLYRYIQPWESEFIDSQRVWAEY
ALKRQEAIAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVR
TDFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTL
FKGTYFPTWEGLFWEKNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGI
FMHGKIPTLKISLIQIFRAHLWQKIHESIVMDLCQVFDQELDALEIETVQ
KETIHPRKSYKMNSSCADILLFASYKWNVSRPSLLADSKDVMDSTTTQKY
WIDIQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYN
LHSAYGNWFPGSKPLIQQAMAKIMKANPALYVLRERIRKGLQLYS
Ligand information
>8q7v Chain 5 (length=104) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acucugguuucucuucagaucgcauaaaucuuucgcacuaaagauuuccg
uggagaggaacaacucugaguccaauuuuuugaggccuugcuuuggcaag
gcua
<<<<.<<<<<<<<<<<<........<<<<<<<<......>>>>>>>>...
>>>>>>>>>>>....>.>>>>............<<<<<<<<....>>>>>
>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8q7v Structural basis of human U5 snRNP late biogenesis and recycling.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		H97 R217 G222 T224 E280 R409 R417 R419 P425 K428 N457 H461 R462 P464 K465 A466 Q467 K469 R470 R474 K477 Y596 K597 M599 R635 F639 R642 G643 L647
Binding residue
(residue number reindexed from 1)		H51 R169 G174 T176 E232 R348 R356 R358 P364 K367 N396 H400 R401 P403 K404 A405 Q406 K408 R409 R413 K416 Y535 K536 M538 R574 F578 R581 G582 L586
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030623 U5 snRNA binding
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0097157 pre-mRNA intronic binding
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0071222 cellular response to lipopolysaccharide
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0030532 small nuclear ribonucleoprotein complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q7v, PDBe:8q7v, PDBj:8q7v
PDBsum8q7v
PubMed38467876
UniProtQ6P2Q9|PRP8_HUMAN Pre-mRNA-processing-splicing factor 8 (Gene Name=PRPF8)

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