Structure of PDB 8q7e Chain A Binding Site BS01

Receptor Information
>8q7e Chain A (length=947) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LMVPLRLQAYPEELIRQRHDGHPEYLIRWSVLKCEHILMWLSAPEVYANC
PGLLDEVAMGEMEADVQALVRRAARQLAESGTPSLTAAVLHTIHVLSAYA
SIGPLTGVFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAH
VLLSLSQQHMDFDSRYTLLELFAETTSSEEHCMAFEGIHLPQIPGKLLFS
LVKRYLCVTSLLDQLNSRGQRELEFSMAVGNLISELVRSMGWARPTRSIF
QPLYPLPYLQPTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLGEISVSVE
MAESLLQVLSSRFEGSTLNDLLNSQIYTKYLSVLRVITRLLDFPEAMVLP
WHEVLEPCLNCLSDSEIVQELTCFLHRLASHKDYAVVLCCLGAKEILSKV
LDKHGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRTHQP
INIPFFDVFLRHLCQFWPLFREQLCRRTCLFYTIRAQAWSRDIAEDHRRL
LQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLVQNITSP
DAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPS
SSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPRYCKLYEHLQRAGSELF
GPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGGLIGGAP
GVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFSWLEGAVL
EQIGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEPSP
AISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQNHRR
LQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLSP
ELLLQALVPLTSGNGPLTLHEGVLRLHEPGSGEALWLIPPQAYLNVE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8q7e Noncanonical assembly, neddylation and chimeric cullin RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
Resolution4.4 Å
Binding residue
(original residue number in PDB)		A1694 S1696 L1698 L1700 Q1753 W1754 T1755 R1759 A1760 E1761
Binding residue
(residue number reindexed from 1)		A801 S803 L805 L807 Q852 W853 T854 R858 A859 E860
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007088 regulation of mitotic nuclear division
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031461 cullin-RING ubiquitin ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8q7e, PDBe:8q7e, PDBj:8q7e
PDBsum8q7e
PubMed38605244
UniProtQ8IWT3|CUL9_HUMAN Cullin-9 (Gene Name=CUL9)

[Back to BioLiP]