Structure of PDB 8q74 Chain A Binding Site BS01

Receptor Information
>8q74 Chain A (length=783) Species: 39947 (Oryza sativa Japonica Group) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDVNKVHLKLEGVSSPEDIKLIQSRLESVEGVNNVECDTAGQTIIVAYDP
DVTGPRLLIQCIQDAAQPPKYFNASLYSPPKQREAERHHEIRNYRNQFLW
SCLFSVPVFMFSMVLPMISPFGDWLFYKVCNNMTIGMLLRWLLCSPVQFI
IGWRFYVGAYHALKRGYSNMDVLVALGTNAAYFYSVYIVLKALTSESFEG
QDFFETSAMLISFILLGKYLEVVAKGKTSDALSKLTELAPETACLLTLDK
DGNAISETEISTQLLQRNDVIKIVPGEKVPVDGVVIKGQSHVNESMITGE
ARPIAKKPGDKVIGGTVNDNGCIIVKVTHVGSETALSQIVQLVEAAQLAR
APVQKLADRISRFFVPTVVVAAFLTWLGWFVAGQFDIYPREWIPKAMDSF
ELALQFGISVLVVACPCALGLATPTAVMVATGKGASQGVLIKGGNALEKA
HKVKAIIFDKTGTLTVGKPSVVQTKVFSKIPLLELCDLAAGAEANSEHPL
SKAIVEYTKKLREQYGSHSDHIMESKDFEVHPGAGVSANVEGKLVLVGNK
RLMQEFEVPISSEVEGHMSETEELARTCVLVAIDRTICGALSVSDPLKPE
AGRAISYLSSMGISSIMVTGDNWATAKSIAKEVGIGTVFAEIDPVGKAEK
IKDLQMKGLTVAMVGDGINDSPALAAADVGLAIGAGTDVAIEAADIVLMR
SSLEDVITAIDLSRKTLSRIRLNYVWALGYNVLGMPVAAGVLFPFTGIRL
PPWLAGACMAASSVSVVCSSLLLQLYKKPLHVE
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain8q74 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8q74 Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases.
Resolution3.68 Å
Binding residue
(original residue number in PDB)		M352 C597 C599
Binding residue
(residue number reindexed from 1)		M170 C415 C417
Annotation score1
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0140581 P-type monovalent copper transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0035434 copper ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q74, PDBe:8q74, PDBj:8q74
PDBsum8q74
PubMed38538615
UniProtQ6H7M3|HMA4_ORYSJ Copper-transporting ATPase HMA4 (Gene Name=HMA4)

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