Structure of PDB 8q3k Chain A Binding Site BS01

Receptor Information
>8q3k Chain A (length=1420) Species: 10498 (African swine fever virus BA71V) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEAGYAEIAAVQFNIAGDNDHKRQGVMEVTISNLFEGTLPAEGGIYDARM
GTTDHHYKCITCSHQRKQCMGHPGILQMHAPVLQPLFIAEIRRWLRVICL
NCGAPIVDLKRYEHLIRPKRLIEAASSQTEGKQCYVCKAVHPKIVKDSED
YFTFWVDQQGKIDKLYPQIIREIFSRVTYDTVVKLGRSKNSHPEKLVLKA
IQIPPISIRPGIRLGIQSFHDINNVIQYLVRKNLLIPKDLQIVRGQKIPL
NIDRNLQTIQQLYYNFLLDSVSTRPAPSIMRRLPRKEGRIRKSLLGSQVW
SISRSTICGNSDLHLDEVGYPISFARTLQVAETVQHYNINRLMPYFLNGK
RQYPGCSRVYKQITQSVHDIEGLKQDFRLEVGDILYRDVVTGDVAFFNRQ
PSLERSSIGVHRIVVLENPKISTFQMNVSACAWYNADFDGDQMNLWVPWS
VMSRVEAELLCSVRNWFISTKSSGPVNGQVQDSTVGSFLLTRTNTPMGKN
VMNKLHAMGLFQTTQTDPPCFANYSPTDLLDGKSVVSMLLKQTPINYQRA
PTWYSEVYAPYMHYNKQDISTQIRNGELIEGVLDKKAVGAGSSGGIYHLI
SRRYGPQQALKMIFATQQLALNYVRNAGFTVSTADMLLTPEAHQEVQEII
NKLLLESEEINNRLLHGDIMPPIGLTTHDFYEKLQLNALKFPDRILKPIM
NSINPETNGLFQMVATGAKGSNPNMIHIMAGIGQIEINTQRIQPQFSFGR
TLVYYPRFALEAQAYGFICNSYIAGLTSPEFIFGEMNGRFDLINKALSTS
STGYANRKAIFGLQSCIVDYYRRVSIDTRLVQQLYGEDGLDARQLETVRF
ETIMLSDQELEDKFKYTGIQSPLFEEEFSRLKKDRDKYRQIFLNVENFNF
SQLLTDVRQVPVNVASIVKNILLSSTSGVLPFDEKSILQKYAMVKTFCKN
LPYVFINNIQERLQTPIPVYLKRAAALMRMLIRIELATVKTLNITCEQMS
AILDLIRLQYTQSLINYGEAVGILAAQSVSEPLTQYMLDSHHRSNKSGIV
RPQEIFSAKPVEAEQSSEMLLRLKNPEVETNKTYAQEIANSIELITFERL
ILQWHLLYETYSSTKKNVMYPDFASDVEWMTDFLENHPLLQPPEDIANWC
IRLELNKTTMILKSISLESIINSLRAKHPNTYIMHSVENTASGIPIIIRI
YLRESAFRRSTNTRMATDEKIAVNVVDKLLNSTIRGIPGIKNANVVKLMR
HRVDAQGKLVRLDNIYAIKTNGTNIFGAMLDDNIDPYTIVSSSIGDTMEL
YGIEAARQKIISEIRTVMGDKGPNHRHLLMYADLMTRTGQVTSLEKAGLN
AREPSNVLLRMALSSPVQVLTDAAVDSAVNPIYGIAAPTLMGSVPRIGTM
YSDIIMDEKYITENYKSVDS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8q3k Chain A Residue 1501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8q3k Structural characterization of the fully recombinant RNA polymerase from African Swine Fever Virus
Resolution2.92 Å
Binding residue
(original residue number in PDB)		C59 C62 C69 H72
Binding residue
(residue number reindexed from 1)		C59 C62 C69 H72
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q3k, PDBe:8q3k, PDBj:8q3k
PDBsum8q3k
PubMed38383525
UniProtP42486|RPB1_ASFB7 DNA-directed RNA polymerase RPB1 homolog (Gene Name=Ba71V-99)

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