Structure of PDB 8q1r Chain A Binding Site BS01
Receptor Information
>8q1r Chain A (length=288) Species:
10090
(Mus musculus) [
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GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLL
YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGH
IYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYA
VGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGG
YDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDG
HTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEP
Ligand information
>8q1r Chain E (length=9) Species:
32630
(synthetic construct) [
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CDPETGECL
Receptor-Ligand Complex Structure
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PDB
8q1r
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction.
Resolution
1.33 Å
Binding residue
(original residue number in PDB)
Y334 S363 N382 R415 R483 S508 Y525 S555 A556 Y572 F577 S602
Binding residue
(residue number reindexed from 1)
Y10 S39 N58 R91 R159 S184 Y201 S231 A232 Y248 F253 S278
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:8q1r
,
PDBe:8q1r
,
PDBj:8q1r
PDBsum
8q1r
PubMed
37829032
UniProt
Q9Z2X8
|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Gene Name=Keap1)
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