Structure of PDB 8px0 Chain A Binding Site BS01

Receptor Information
>8px0 Chain A (length=121) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KETAAAKFERQHMDSSTSSSNYCNQMMKSRNLTKDRCKPVNTFVHESLAD
VQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQAN
KHIIVACEGNPYVPVHFDASV
Ligand information
Ligand ID0U
InChIInChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m0/s1
InChIKeyDJJCXFVJDGTHFX-PSQAKQOGSA-N
SMILES
SoftwareSMILES
CACTVS 3.352O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@@H]2[C@H]([C@H]([C@@H](O2)COP(=O)(O)O)O)O
CACTVS 3.352O[C@@H]1[C@H](O)[C@H](O[C@H]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
ACDLabs 11.02O=P(O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H13 N2 O9 P
NameL-URIDINE-5'-MONOPHOSPHATE
ChEMBL
DrugBank
ZINCZINC000001532538
PDB chain8px0 Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8px0 Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		Q11 H12 K41 V43 N44 T45 H119 F120
Binding residue
(residue number reindexed from 1)		Q11 H12 K38 V40 N41 T42 H116 F117
Annotation score1
Enzymatic activity
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8px0, PDBe:8px0, PDBj:8px0
PDBsum8px0
PubMed37828292
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

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