Structure of PDB 8pu0 Chain A Binding Site BS01

Receptor Information
>8pu0 Chain A (length=1157) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRNLKLFRTLEFRDIQGPGNPQCFSLRTEQGTVLIGSEHGLIEVDPVSRE
VKNEVSLVAEGFLPEDGSGRIVGVQDLLDQESVCVATASGDVILCSLSTQ
QLECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPILEQQIHQ
DDFGESKFITVESALPWDDHRPQVTWRGDGQFFAVSVVCPETGARKVRVW
NREFALQSTSEPVAGLGPALAWKPSGSLIASTQDKPNQQDIVFFEKNGLL
HGHFTLPFLKDEVKVNDLLWNADSSVLAVWLEDLQKTCVQLWTVGNYHWY
LKQSLSFSTCGKSKIVSLMWDPVTPYRLHVLCQGWHYLAYDWHWTTDRSV
GDNSSDLSNVAVIDGNRVLVTVFRQTVVPPPMCTYQLLFPHPVNQVTFLA
HPQKSNDLAVLDASNQISVYKCGDCPSADPTVKLGAVGGSGFKVCLRTPH
LEKRYKIQFPLKLGLLTWIEEDVFLAVSHSEFSPRSVIHHLTAASSEMDE
EHGQLNVSSSAAVDGVIISLCCNSKTKSVVLQLADGQIFKYLWESPSLAI
KPWKNSGGFPVRFPYPCTQTELAMIGEEECVLGLTDRCRFFINDIEVASN
ITSFAVYDEFLLLTTHSHTCQCFCLRDASFKTLQAGLSSNHVSHGEVLRK
VERGSRIVTVVPQDTKLVLQMPRGNLEVVHHRALVLAQIRKWLDKLMFKE
AFECMRKLRINLNLIYDHNPKVFLGNVETFIKQIDSVNHINLFFTELKEE
DVTKTMYPAPVGNKIDLVCDAMRAVMESINPHKYCLSILTSHVKKTTPEL
EIVLQKVHELQGNADAVSAEEALKYLLHLVDVNELYDHSLGTYDFDLVLM
VAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKAIGHLSKCGP
EYFPECLNLIKDKNLYNEALKLYSPSSQQYQDISIAYGEHLMQEHMYEPA
GLMFARCGAHEKALSAFLTCGNWKQALCVAAQLNFTKDQLVGLGRTLAGK
LVEQRKHIDAAMVLEECAQDYEEAVLLLLEGAAWEEALRLVYKYNRLDII
ETNVKPSILEAQKNYMAFLDSQTATFSRHKKRLLVVEALSEVVQNTENLK
DEVYHILKVLFLFEFDEQGRELQKAFEDTLQLMERSLPEIWPPKINRRTQ
WKLSLLD
Ligand information
>8pu0 Chain X (length=71) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccccaugguguaaugguuagcacucuggacuuugaauccagcgauccg
aguucaaaucucggugggacc
<<.<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<
<<.......>>>>>>>>>.>>
Receptor-Ligand Complex Structure
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PDB8pu0 Cryo-EM structure of human Elp123 in complex with tRNA, desulpho-CoA, 5'-deoxyadenosine and methionine
Resolution4.25 Å
Binding residue
(original residue number in PDB)		R1133 H1134
Binding residue
(residue number reindexed from 1)		R1078 H1079
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006417 regulation of translation
GO:0008033 tRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0033588 elongator holoenzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pu0, PDBe:8pu0, PDBj:8pu0
PDBsum8pu0
PubMed38750017
UniProtO95163|ELP1_HUMAN Elongator complex protein 1 (Gene Name=ELP1)

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