Structure of PDB 8pok Chain A Binding Site BS01

Receptor Information
>8pok Chain A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAI
TDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMI
SLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRN
ESKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS
SWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLE
AIVLWLGYANSALNPILYAALNRDFRTG
Ligand information
Ligand IDHSM
InChIInChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKeyNTYJJOPFIAHURM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1c(nc[nH]1)CCN
CACTVS 3.341NCCc1c[nH]cn1
ACDLabs 10.04n1c(cnc1)CCN
FormulaC5 H9 N3
NameHISTAMINE
ChEMBLCHEMBL90
DrugBankDB05381
ZINCZINC000000388081
PDB chain8pok Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8pok Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G s complex in nanodisc environment.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D104 Y256
Binding residue
(residue number reindexed from 1)		D86 Y230
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0030594 neurotransmitter receptor activity
Biological Process
GO:0001696 gastric acid secretion
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 chemical synaptic transmission
GO:0045907 positive regulation of vasoconstriction
GO:0098664 G protein-coupled serotonin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pok, PDBe:8pok, PDBj:8pok
PDBsum8pok
PubMed38418462
UniProtP25021|HRH2_HUMAN Histamine H2 receptor (Gene Name=HRH2)

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