Structure of PDB 8po2 Chain A Binding Site BS01
Receptor Information
>8po2 Chain A (length=271) Species:
9606
(Homo sapiens) [
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RILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK
ANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDY
VREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV
KITDFGLAKLLGVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSK
PYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRE
LIIEFSKMARDPQRYLVIQGD
Ligand information
>8po2 Chain D (length=18) Species:
9606
(Homo sapiens) [
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MDEEDMDDVVDADEYLIP
Receptor-Ligand Complex Structure
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PDB
8po2
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
Resolution
2.28 Å
Binding residue
(original residue number in PDB)
R779 K826 K849 H853 K855 I969 R976
Binding residue
(residue number reindexed from 1)
R75 K122 K145 H149 K151 I253 R260
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:8po2
,
PDBe:8po2
,
PDBj:8po2
PDBsum
8po2
PubMed
38770784
UniProt
P00533
|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)
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