Structure of PDB 8pnp Chain A Binding Site BS01

Receptor Information
>8pnp Chain A (length=708) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFASICTHLEVCFMYSD
FHFIDERGESTIILKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPD
LYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATK
ADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEIT
GTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIE
PFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAI
KCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIKNEEKIPRTK
NMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRSLACWIQ
SEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEY
IMKGVYINTALLNASCAAMDDFQLIPMISKCITKEGRRKTNLYGFIIKGR
SHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAVGQVS
RPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDLT
KEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGF
SAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLLNASWFN
SFLTHALR
Ligand information
>8pnp Chain V (length=29) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguagaaacaaggguccccugcuuuugcu
.<<....>>.<<<<..>>>>.........
Receptor-Ligand Complex Structure
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PDB8pnp The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		H326 K328 G371 N373 M374 A375 P376 K378 Y393 D394 S395 E397 P398 M477 R508 H510 L511 R512 V517 N519 K539 R566 T567 N568 G569 K574
Binding residue
(residue number reindexed from 1)		H318 K320 G363 N365 M366 A367 P368 K370 Y385 D386 S387 E389 P390 M469 R500 H502 L503 R504 V509 N511 K531 R558 T559 N560 G561 K566
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pnp, PDBe:8pnp, PDBj:8pnp
PDBsum8pnp
PubMed38316757
UniProtM9TI86

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