Structure of PDB 8pi3 Chain A Binding Site BS01
Receptor Information
>8pi3 Chain A (length=219) Species:
9606
(Homo sapiens) [
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RILPDSVDWREKGCVTEVKDQGSCGACWAFSAVGALEAQLKLKTGKLVSL
SAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQK
CQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLY
RSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRM
ARNKGNHCGIASFPSYPEI
Ligand information
>8pi3 Chain B (length=8) Species:
32630
(synthetic construct) [
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AKHRMVMW
Receptor-Ligand Complex Structure
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PDB
8pi3
Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Resolution
1.73 Å
Binding residue
(original residue number in PDB)
S135 C136 G137 C139 N181 G182 G183 F184 M185 V276 N277 F325
Binding residue
(residue number reindexed from 1)
S23 C24 G25 C27 N69 G70 G71 F72 M73 V164 N165 F213
Enzymatic activity
Enzyme Commision number
3.4.22.27
: cathepsin S.
External links
PDB
RCSB:8pi3
,
PDBe:8pi3
,
PDBj:8pi3
PDBsum
8pi3
PubMed
38811854
UniProt
P25774
|CATS_HUMAN Cathepsin S (Gene Name=CTSS)
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