Structure of PDB 8pfl Chain A Binding Site BS01

Receptor Information

>8pfl Chain A (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEEARDNVAVMA
TGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSA
QSANVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHC
ISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRN
PQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCP
SRKMTQQVTGELAKLNLSCGTYHAGMSFSTAKDIHHRFVRDEIQCVIATI
AFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPAD
INLNRHLLTEIRNAKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQV
QKASLGIMGTEKCCDNCRSALD

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8pfl Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	8pfl A WRN inhibitor shows anti-tumor efficacy in MSI-high tumor models
Resolution	1.8 Å
Binding residue (original residue number in PDB)	C908 C935 C936 C939
Binding residue (residue number reindexed from 1)	C386 C413 C414 C417
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.-.-
5.6.2.4: DNA 3'-5' helicase.

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005524	ATP binding

	Biological Process
GO:0006310	DNA recombination

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8pfl, PDBe:8pfl, PDBj:8pfl
PDBsum	8pfl
PubMed	38658754
UniProt	Q14191\|WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Gene Name=WRN)

[Back to BioLiP]