Structure of PDB 8pfh Chain A Binding Site BS01

Receptor Information
>8pfh Chain A (length=272) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQFNIMVVGQSGLGKSTLINTLFASHLIDSATGDDISALPVTKTTEMKIS
THTLVEDRVRLNINVIDTPGFGDFIDNSKAWEPIVKYIKEQHSQYLRKEL
TAQRERFITDTRVHAILYFLQPNGKELSRLDVEALKRLTEIANVIPVIGK
SDTLTLDERTEFRELIQNEFEKYNFKIYPYDSEELTDEELELNRSVRSII
PFAVVGSENEIEINRGRKTRWSAINVEDINQCDFVYLREFLIRTHLQDLI
ETTSYIHYEGFRARQLIALKEN
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain8pfh Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pfh Crystal structure of the yeast septin complex Shs1-Cdc12-Cdc3-Cdc10
Resolution3.24 Å
Binding residue
(original residue number in PDB)		G42 G44 K45 S46 T47 K180 V235 R251
Binding residue
(residue number reindexed from 1)		G12 G14 K15 S16 T17 K150 V205 R217
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005545 1-phosphatidylinositol binding
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0060090 molecular adaptor activity
GO:0070273 phosphatidylinositol-4-phosphate binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0000920 septum digestion after cytokinesis
GO:0000921 septin ring assembly
GO:0008104 protein localization
GO:0010458 exit from mitosis
GO:0032186 cellular bud neck septin ring organization
GO:0043934 sporulation
GO:0051301 cell division
GO:0061640 cytoskeleton-dependent cytokinesis
Cellular Component
GO:0000144 cellular bud neck septin ring
GO:0001400 mating projection base
GO:0005619 ascospore wall
GO:0005628 prospore membrane
GO:0005876 spindle microtubule
GO:0005935 cellular bud neck
GO:0005940 septin ring
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0031105 septin complex
GO:0032153 cell division site
GO:0032160 septin filament array
GO:0042764 ascospore-type prospore
GO:0043332 mating projection tip
GO:0072687 meiotic spindle
GO:1990317 Gin4 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pfh, PDBe:8pfh, PDBj:8pfh
PDBsum8pfh
PubMed38184752
UniProtP25342|CDC10_YEAST Cell division control protein 10 (Gene Name=CDC10)

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