Structure of PDB 8pd9 Chain A Binding Site BS01

Receptor Information
>8pd9 Chain A (length=1024) Species: 7668 (Strongylocentrotus purpuratus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHAPKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVP
LVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILAL
FGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLG
ASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQV
AVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEV
SGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVV
VTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRN
AVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINA
TTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADA
DWDIATAACEISDPYSPSPREFADMMEEARLRMLKAEKISYWKQFEHGML
AREALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLIS
HHMAFEVTINIAIVLNIVPIIMEFVVQDKMALQKIEDALRISNYVFFVIY
AIEAIVKILGLGRHYIVSHWNKFDAFILVVALVDIIIAETSSIKVVKLFR
LLRGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKI
IDRMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIR
TILNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPP
ENLLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVS
GLVKLYGKSVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAE
DMNIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHL
ERGYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTV
HKLTFQYTATEEPRLFVVRNAEYN
Ligand information
Ligand IDCMP
InChIInChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKeyIVOMOUWHDPKRLL-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C4C(O3)COP(=O)(O4)O)O)N
ACDLabs 10.04O=P3(OCC4OC(n1c2ncnc(N)c2nc1)C(O)C4O3)O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@](=O)(O4)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH]4CO[P](O)(=O)O[CH]4[CH]3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@](O)(=O)O[C@H]4[C@H]3O
FormulaC10 H12 N5 O6 P
NameADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE;
CYCLIC AMP;
CAMP
ChEMBLCHEMBL316966
DrugBankDB02527
ZINCZINC000003873977
PDB chain8pd9 Chain A Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pd9 Structures of a sperm-specific solute carrier gated by voltage and cAMP.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		L1008 F1032 G1043 G1046 R1053 N1054 R1097
Binding residue
(residue number reindexed from 1)		L855 F861 G872 G875 R882 N883 R926
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015297 antiporter activity
GO:0015385 sodium:proton antiporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0055085 transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8pd9, PDBe:8pd9, PDBj:8pd9
PDBsum8pd9
PubMed37880361
UniProtA3RL54|SL9C1_STRPU Sperm-specific sodium:proton exchanger (Gene Name=SLC9C1)

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