Structure of PDB 8pay Chain A Binding Site BS01

Receptor Information
>8pay Chain A (length=370) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGSHMKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTG
TDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGER
MLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSM
AHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVP
RKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRR
VLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANN
PEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSS
VQIEDAASQSAAYVVMPMRL
Ligand information
Receptor-Ligand Complex Structure
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PDB8pay Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp.
Resolution1.21 Å
Binding residue
(original residue number in PDB)		R152 G174 H175 P242 M362 P363 M364 R365
Binding residue
(residue number reindexed from 1)		R156 G178 H179 P246 M366 P367 M368 R369
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032297 negative regulation of DNA-templated DNA replication initiation
GO:0042276 error-prone translesion synthesis
GO:0044787 bacterial-type DNA replication
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009360 DNA polymerase III complex
GO:0030894 replisome
GO:1990078 replication inhibiting complex
GO:1990085 Hda-beta clamp complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pay, PDBe:8pay, PDBj:8pay
PDBsum8pay
PubMed38425897
UniProtP0A988|DPO3B_ECOLI Beta sliding clamp (Gene Name=dnaN)

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