Structure of PDB 8p9b Chain A Binding Site BS01

Receptor Information
>8p9b Chain A (length=263) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSH
IHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVS
PVKICDFSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPF
VGRCCPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQR
LSAAQVLQHPWVQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8p9b Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p9b Crystal Structure of Mnk2-D228G in complex with Tinodasertib
Resolution2.59 Å
Binding residue
(original residue number in PDB)		C299 C311 C314
Binding residue
(residue number reindexed from 1)		C204 C205 C208
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
External links
PDB RCSB:8p9b, PDBe:8p9b, PDBj:8p9b
PDBsum8p9b
PubMed
UniProtQ9HBH9|MKNK2_HUMAN MAP kinase-interacting serine/threonine-protein kinase 2 (Gene Name=MKNK2)

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