Structure of PDB 8p1m Chain A Binding Site BS01

Receptor Information
>8p1m Chain A (length=1298) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YIPDYKGMEPIGANIEDLVDYSKDWLSRARNFSFFEVKGTAVFECFNSNE
ANHCQRYPMSRKPRNFLLIQCSLITSYKPATTLSDQIDSRRACSYILNLI
PDTPASYLIHDMAYRYINLTREDMINYYAPRIQFKQTQNVREPGTFKLTS
SMLRAESKAMLDLLNIESLNIASHIVQSESVSLITKILSDLELNITDTVL
DKFFQNETQKYLIDVLKKTTAWHIGHLIRDITESLIAHSGLKRSKYWSLH
SYNNGNVILFILPSKSLEVAGSFIRFITVFRIGPGLVDKDNLDTILIDGD
SQWGVSKVMSIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQYAI
RSVFANHFLLAICQKMKLCAIFDNLRYLIPAVTSLYSGFPSLIEKLFERP
FKSSLEVYIYYNIKSLLVALAQNNVYPSFMSRIVYKHYRSLISEVTTCFF
LFEKGLHGNMNEEAKIHLETVEWALKFREKEEKYGESLVENGYMMWELRA
NAELAEQQLYCQDAIELAAIELNKVLATKSSVVANSILSKNWEEPYFSQT
RNISLKGMSGQVQEDGHLSSSVTIIEAIRYLSNSRHNPSLLKLYEETREQ
KAMARIVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAIAKNISEEYIS
YGGEKKILAIQGALEKALRWASGESFIELSNHKFIRMKRKLMYVSADATK
WSPGDNSAKFRRFTSMLHNGLPNNKLKNCVIDALKQVYKTDFFMSRKLRN
YIDSMESLDPHIKQFLDFFPDGHHGEVKGNWLQGNLNKCSSLFGVAMSLL
FKQVWTNLFPELDCFFEFAHHSDDALFIYGYLEPVDDGTDWFLFVSQQIQ
AGHLHWFSVNTEMWKSMFNLHEHILLLGSIKISPKKTTVSPTNAEFLSTF
FEGCAVSIPFVKILLGSLSDLPGLGYFDDLAAAQSRCVKALDLGASPQVA
QLAVALCTSKVERLYGTAPGMVNHPAAYLQVKHTDTPIPLGGNGAMSIME
LATAGIGMSDKNLLKRALLGYSHKRQKSMLYILGLFKFLMKLSDETFQHE
RLGQFSFIGKVQWKIFTPKSEFEFADMYTSKFLELWSSQHVTYDYIIPKG
RDNLLIYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCRLDGEWVT
FREVLAAANSFAENYSATSQDMDLFQTLTSRAKVARTFTVREKDQIIQNS
IPAVIGYKFAVTVEEMSDVLDTAKFPDSLSVDLKTMKDGVYRELGLDISL
PDVMKRIAPMLYKSSKSRVVIVQGNVEGTAEAICRYWLKSMSLVKTIR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p1m Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA and NTP Mg
Resolution3.23 Å
Binding residue
(original residue number in PDB)		L389 F524 K558 V559 S561 R566 K616 K618 K653 H732 N736
Binding residue
(residue number reindexed from 1)		L164 F273 K307 V308 S310 R315 K365 K367 K402 H457 N461
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004519 endonuclease activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0039689 negative stranded viral RNA replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044220 host cell perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p1m, PDBe:8p1m, PDBj:8p1m
PDBsum8p1m
PubMed
UniProtP23456|L_HANTV RNA-directed RNA polymerase L (Gene Name=L)

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