Structure of PDB 8ouh Chain A Binding Site BS01

Receptor Information
>8ouh Chain A (length=440) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFP
GELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLA
SALGVGLALALQPGAASAAINASAENAPSKEVLDSFLDLARNIFPSNLVS
AAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKL
GPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLL
FARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAF
GTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAA
VFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNL
PVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDR
Ligand information
Ligand IDALA
InChIInChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
InChIKeyQNAYBMKLOCPYGJ-REOHCLBHSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C(=O)O)N
CACTVS 3.341C[CH](N)C(O)=O
ACDLabs 10.04O=C(O)C(N)C
CACTVS 3.341C[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0C[C@@H](C(=O)O)N
FormulaC3 H7 N O2
NameALANINE
ChEMBLCHEMBL279597
DrugBankDB00160
ZINCZINC000004658553
PDB chain8ouh Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ouh Receptor-recognition and antiviral mechanisms of human placental proteins
Resolution2.62 Å
Binding residue
(original residue number in PDB)		S353 M387 G430 D464
Binding residue
(residue number reindexed from 1)		S305 M339 G382 D416
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015186 L-glutamine transmembrane transporter activity
GO:0015194 L-serine transmembrane transporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
GO:0022834 ligand-gated channel activity
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0006868 glutamine transport
GO:0010585 glutamine secretion
GO:0015804 neutral amino acid transport
GO:0015825 L-serine transport
GO:0030218 erythrocyte differentiation
GO:0046718 symbiont entry into host cell
GO:0070207 protein homotrimerization
GO:0140009 L-aspartate import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1903803 L-glutamine import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ouh, PDBe:8ouh, PDBj:8ouh
PDBsum8ouh
PubMed38671230
UniProtQ15758|AAAT_HUMAN Neutral amino acid transporter B(0) (Gene Name=SLC1A5)

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