Structure of PDB 8oud Chain A Binding Site BS01

Receptor Information
>8oud Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLR
LLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVG
LALALQPGAASKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERKVPVG
QEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWI
MWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPL
IYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKH
ISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATA
SSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVE
GDALGAGLLQNYVDRT
Ligand information
Ligand IDALA
InChIInChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
InChIKeyQNAYBMKLOCPYGJ-REOHCLBHSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C(=O)O)N
CACTVS 3.341C[CH](N)C(O)=O
ACDLabs 10.04O=C(O)C(N)C
CACTVS 3.341C[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0C[C@@H](C(=O)O)N
FormulaC3 H7 N O2
NameALANINE
ChEMBLCHEMBL279597
DrugBankDB00160
ZINCZINC000004658553
PDB chain8oud Chain A Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8oud Receptor-recognition and antiviral mechanisms of human placental proteins.
Resolution2.31 Å
Binding residue
(original residue number in PDB)		S351 S353 G430 I431 D464 T468 N471
Binding residue
(residue number reindexed from 1)		S278 S280 G357 I358 D391 T395 N398
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015186 L-glutamine transmembrane transporter activity
GO:0015194 L-serine transmembrane transporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
GO:0022834 ligand-gated channel activity
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0006868 glutamine transport
GO:0010585 glutamine secretion
GO:0015804 neutral amino acid transport
GO:0015825 L-serine transport
GO:0030218 erythrocyte differentiation
GO:0046718 symbiont entry into host cell
GO:0070207 protein homotrimerization
GO:0140009 L-aspartate import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1903803 L-glutamine import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oud, PDBe:8oud, PDBj:8oud
PDBsum8oud
PubMed38671230
UniProtQ15758|AAAT_HUMAN Neutral amino acid transporter B(0) (Gene Name=SLC1A5)

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