Structure of PDB 8ost Chain A Binding Site BS01

Receptor Information
>8ost Chain A (length=390) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLGLKQAEERLERDHIFRLEKRSPEYTNCRYLCKLCLIHIENIQGAHKHI
KEKRHKKNILEKQEESELRSLPPPSPAHLAALSVAVIELAKEHGITDDDL
RVRQEVEEMSKVITTFLPECSLRLYGSSLTRFALKSSDVNIDIKFPPKMN
HPDLLIKVLGILKKNVLYVDVESDFHAKVPVVVCLCRVSAGNDMACLTTD
LLTALGKIEPVFIPLVLAFRYWAKLCYIDSQTDGGIPSYCFALMVMFFLQ
QRKPPLLPCLLGSWIEGFDPKRMDDFQLKGIVEEKFVKWECLALETPNRV
SLGQLWLELLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRIAIEDPF
SVKRNVARSLNSQLVYEYVVERFRAAYRYFACPQTKGGNK
Ligand information
>8ost Chain C (length=69) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguaguaguuuguacaguuugagggucuaugauacaacccgguacaggag
auaacuguacaggccacug
..<<<<.<<.<<<<<<<<<...............................
..>>>>>>>>>.>>.>>>>
Receptor-Ligand Complex Structure
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PDB8ost Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Resolution3.69 Å
Binding residue
(original residue number in PDB)		H320 K324 R327 R669 R670
Binding residue
(residue number reindexed from 1)		H47 K51 R54 R342 R343
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0035198 miRNA binding
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
Biological Process
GO:0001556 oocyte maturation
GO:0010586 miRNA metabolic process
GO:0010587 miRNA catabolic process
GO:0019827 stem cell population maintenance
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031054 pre-miRNA processing
GO:0031123 RNA 3'-end processing
GO:0071044 histone mRNA catabolic process
GO:0071076 RNA 3' uridylation
GO:0141008 retrotransposon silencing by mRNA destabilization
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0070062 extracellular exosome

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Biological Process
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Cellular Component
External links
PDB RCSB:8ost, PDBe:8ost, PDBj:8ost
PDBsum8ost
PubMed39054354
UniProtQ5TAX3|TUT4_HUMAN Terminal uridylyltransferase 4 (Gene Name=TUT4)

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