Structure of PDB 8osi Chain A Binding Site BS01

Receptor Information
>8osi Chain A (length=400) Species: 5061,7740 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLPATHELHIFGSINGIDFDMVGQGTGNPNDGYEELNLKSTMGDLQFSPW
ILVPHIFHQYLPYPDGMSPFQAAMVDGSGYQVHRTMQFEDGATLTVNYRY
TYEGSHIKGEAQVEGTGFPADGPVMTNSLTAEAQMADSLTEEQVSEYKEL
FSLFDLDGDGQITTKELGTVMRSLDLNPSESELQDMINEVDAGGDGTIDF
PEFLTMMTREMKYRDTEEEIRELCKVFDRDNDGFIVAAELRHAMTSIGEE
LTDDEVDEMIREADQDGDGRIDYNEFVQLKMQKSGMRRLLKKAIDTVRAI
NRLREGMYFADWCVSKKTCPDDKTIVSTLKWAFITDNGKRYRSTARTTYT
FAKPMAANYLKNQPMYVFRKTELIHSKTELNFKEWQKAFTDGMGMDELYK
Ligand information
Ligand IDCR2
InChIInChI=1S/C13H13N3O4/c14-6-11-15-10(13(20)16(11)7-12(18)19)5-8-1-3-9(17)4-2-8/h1-5,17H,6-7,14H2,(H,18,19)/b10-5-
InChIKeyIZZXWFHPOZIXIE-YHYXMXQVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1cc(ccc1C=C2C(=O)N(C(=N2)CN)CC(=O)O)O
OpenEye OEToolkits 1.5.0c1cc(ccc1\C=C/2\C(=O)N(C(=N2)CN)CC(=O)O)O
ACDLabs 10.04O=C1C(\N=C(N1CC(=O)O)CN)=C\c2ccc(O)cc2
CACTVS 3.341NCC1=N\C(=C/c2ccc(O)cc2)C(=O)N1CC(O)=O
CACTVS 3.341NCC1=NC(=Cc2ccc(O)cc2)C(=O)N1CC(O)=O
FormulaC13 H13 N3 O4
Name{(4Z)-2-(aminomethyl)-4-[(4-hydroxyphenyl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid;
CHROMOPHORE (GLY-TYR-GLY)
ChEMBL
DrugBankDB03998
ZINCZINC000058632170
PDB chain8osi Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8osi FNCaMP, ratiometric green calcium indicator based on mNeonGreen protein.
Resolution2.42 Å
Binding residue
(original residue number in PDB)		P65 H66 I67 F71 H72 R98 Y114 C334 R390 E405
Binding residue
(residue number reindexed from 1)		P54 H55 I56 F57 H58 R84 Y100 C313 R369 E384
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0005509 calcium ion binding
GO:0030234 enzyme regulator activity
GO:0046872 metal ion binding
Biological Process
GO:0006414 translational elongation
GO:0008218 bioluminescence
GO:0051300 spindle pole body organization
Cellular Component
GO:0005823 central plaque of spindle pole body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8osi, PDBe:8osi, PDBj:8osi
PDBsum8osi
PubMed37163937
UniProtA0A100IBH9;
A0A1S4NYF2;
A0A254U4M1

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