Structure of PDB 8ops Chain A Binding Site BS01

Receptor Information
>8ops Chain A (length=403) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEGPVIDESVLSTKELLGLQQAEERLKRDCIDRLKRRPRNYPTAKYTCRL
CDVLIESIAFAHKHIKEKRHKKNIKEKQEEELLTTLPPPTPSQINAVGIA
IDKVVQEFGLHNENLEQRLEIKRIMENVFQHKLPDCSLRLYGSSCSRLGF
KNSDVNIDIQFPAIMSQPDVLLLVQECLKNSDSFIDVDADVVVCREKQSG
LLCKVSAGNENACLTTKHLTALGKLEPKLVPLVIAFRYWAKLCSIDRPEE
GGLPPYVFALMAIFFLQQRKEPLLPVYLGSWIEGFSLSKLGNFNLQDIEK
DVVIWEHGQVSLILDVKHQPSVPVGQLWVELLRFYALEFNLADLVISIRV
KELVSRELKDWPKKRIAIEDPYSVKRNVARTLNSQPVFEYILHCLRTTYK
YFA
Ligand information
>8ops Chain C (length=69) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguaguaauuuguacaguuugagggucuaugauaccacccgguacaggag
auaacuguacaggccacug
........<<<<<<.<<<<.<.............................
.>>>>>.>>>>>>......
Receptor-Ligand Complex Structure
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PDB8ops Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Resolution3.82 Å
Binding residue
(original residue number in PDB)		R223 R226 H260 K264 K266 N610
Binding residue
(residue number reindexed from 1)		R25 R28 H62 K66 K68 N383
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0035198 miRNA binding
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
GO:0070569 uridylyltransferase activity
Biological Process
GO:0001556 oocyte maturation
GO:0010586 miRNA metabolic process
GO:0031054 pre-miRNA processing
GO:0031123 RNA 3'-end processing
GO:0071044 histone mRNA catabolic process
GO:0071076 RNA 3' uridylation
GO:0141008 retrotransposon silencing by mRNA destabilization
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ops, PDBe:8ops, PDBj:8ops
PDBsum8ops
PubMed39054354
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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