Structure of PDB 8opp Chain A Binding Site BS01

Receptor Information
>8opp Chain A (length=670) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTPSQINAVGIAIDKVVQEFGLHNENLEQRLEIKRIMENVFQHKLPDCSL
RLYGSSCSRLGFKNSDVNIDIQFPAIMSQPDVLLLVQECLKNSDSFIDVD
ADFHARVPVVVCREKQSGLLCKVSAGNENACLTTKHLTALGKLEPKLVPL
VIAFRYWAKLCSIDRPEEGGLPPYVFALMAIFFLQQRKEPLLPVYLGSWI
EGFSLSKLGNFNLQDIEKDVVIWEHTPIKRGQVSLILDVKHQPSVPVGQL
WVELLRFYALEFNLADLVISIRVKELVSRELKDWPKKRIAIEDPYSVKRN
VARTLNSQPVFEYILHCLRTTYKYFATKGKSPTVVCSLCKREGHLKKDCP
EDFKLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQ
DFPGTKLSLFGSSKNGFGFKQSDLDVCMTIVRTIEELARVLRKHSGLRNI
LPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKY
LCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPPVIPVLQEIG
WNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRFYTEEFDFKEHVISI
RRKSLLTTFKKQWTSIVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRV
FGIPVKPSKMEYFFDPDVLT
Ligand information
>8opp Chain D (length=25) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugagguaguagugccacugccuugc
.<.<<<<<<......>>>>.>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8opp Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Resolution3.76 Å
Binding residue
(original residue number in PDB)		R592 I1099 T1101 K1103 I1106 D1119 N1124 S1164
Binding residue
(residue number reindexed from 1)		R288 I453 T455 K457 I460 D473 N478 S518
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0035198 miRNA binding
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
GO:0070569 uridylyltransferase activity
Biological Process
GO:0001556 oocyte maturation
GO:0010586 miRNA metabolic process
GO:0031054 pre-miRNA processing
GO:0031123 RNA 3'-end processing
GO:0071044 histone mRNA catabolic process
GO:0071076 RNA 3' uridylation
GO:0141008 retrotransposon silencing by mRNA destabilization
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8opp, PDBe:8opp, PDBj:8opp
PDBsum8opp
PubMed39054354
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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