Structure of PDB 8oox Chain A Binding Site BS01

Receptor Information

>8oox Chain A (length=437) Species: 1122233 (Methermicoccus shengliensis DSM 18856)

SKEDEIFRIVEEKNVRFVRLQFVDVQGIPKNVAIPVGQLEKALGPGIHFD
GSSIEGFVRIEESDMVLRPDPDTFRVLPWSGTAEARLICDIELPDGKPFM
GCPRQVLKKNMEEAAKLGYVMNTGPEMEFFLFKRQDGMPTNIPQDRGGYF
DLAPIDLAEEIKREIVLVLEEMGFEVEAAHHEVAFGQHEIDFKYDNALAT
ADNVITLKYVAKTLALQHGLHATFMPKPIFGVNGSGMHTNTSLFKDGKNA
FYDPDAPDQISDTLRYFVGGVLKHIRAITAITNPLVNSYKRLVPGYEAPV
YITWSGPNRSSLIRVPAPRGNSTRIEIRSPDPSCNPYLAFAAILAAGLDG
VKNKIEPPERVEKNIYKLTEEEREKLGIGMLPGTLKEAIECFKEDELLVS
ALGEHVSQSIINVAMADWDSYRTQVHQWELDRYLQTY

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8oox Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8oox Differences in the regulation mechanisms of the glutamine synthetase from methanogenic archaea unveiled by structural investigations.
• Resolution: 3.09 Å
• Binding residue (original residue number in PDB): E133 E187 E194
• Binding residue (residue number reindexed from 1): E128 E182 E189
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8oox, PDBe:8oox, PDBj:8oox
• PDBsum: 8oox
• PubMed: 38243071
• UniProt: A0A832VZP6