Structure of PDB 8oo6 Chain A Binding Site BS01

Receptor Information
>8oo6 Chain A (length=604) Species: 866768 (Escherichia coli 'BL21-Gold(DE3)pLysS AG') [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHDNYVTILDEETLKAWIAKLEKAPVFAFDTETDSLDNISANLVGLSFA
IEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYD
RGILANYGIELRGIAFDTMLESYILNSVAGRHDMDSLAERWLKHKTITFE
EIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQKHKGPLN
VFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIA
GEEFNLSSTKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLP
KVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDP
NLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLL
TAFAEGKDIHRATAAEVFGLPLETVTSEQRRSAKAINFGLIYGMSAFGLA
RQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLY
LPDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRV
RMIMQVHDELVFEVHKDDVDAVAKQIHQLMENCTRLDVPLLVEVGSGENW
DQAH
Ligand information
Receptor-Ligand Complex Structure
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PDB8oo6 A four-point molecular handover during Okazaki maturation.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		N579 S581 S582 Q585 S638 K643 T672 N675 Y766 M768 S769 F771 R841 N845
Binding residue
(residue number reindexed from 1)		N255 S257 S258 Q261 S314 K319 T348 N351 Y442 M444 S445 F447 R517 N521
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8oo6, PDBe:8oo6, PDBj:8oo6
PDBsum8oo6
PubMed37620586
UniProtP00582|DPO1_ECOLI DNA polymerase I (Gene Name=polA)

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