Structure of PDB 8onz Chain A Binding Site BS01

Receptor Information
>8onz Chain A (length=385) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKKKKKKNKKKKKKPTQQSDPPRVLISHLFPDGKYPAGEEVEYVNENRYR
TTSEEKRYLDNMQSEFLNDYRQAAEVHRQVRKWAQGFVKPGKSLIEISEG
IEDSVRALVGHPGLEEGDALKAGMGFPVGLSINHCAAHYNPNSGNKIVLQ
QDDVIKIDIGVHVNGRIVDSAFTMAWNDQFNPLLEAVRAATNAGIREAGI
DARVGEIGGVIQEVMESYEVEINGKTYPVKPIRNLNGHNILPYSIHGTKS
VPIVKTHDQTKMEEGDVFAIETFGSTGKGYVIESGEVSHYALRGDAPKVD
LRLSSAKSLLNVIKRHFGTLPFCRRFLDRLGQEKYLLGLNNLVSNGIVED
YPPLVDEKGSYTAQFEHTILIRPTVKEVISRGDDY
Ligand information
>8onz Chain 1 (length=270) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
augaaaagcacuuugaaaagaggguuaaauagcaccuucaaugagaacuu
gaaguuccaugugaacagcgguuggacauggguugccgguuaauauuccg
gcacccggaagagcccgacacuucugucgggucaaggguugggcacguug
ggcuuugggcgcgcccugggagcagagggccucuagccgggcaaccggcc
ggcggcccucagcacccgggguagcccuuagcaggcuucggccguccggc
gugcgguuaacaaccaacuu
..........<<<<....>>>>.............<<<<<<.......>>
>>>>..<<<<<<...<<.....>>.>>>>>>...<<<<<........>>>
>>..........<<<<<<<......>>>>>>>.<<<<<<<<.<<<<<<<.
..<<..<<<<...<<<<<<<.<<.<<<<<<<.<<.<<<<<....>>>>>.
>>.>>>>>>>.>>.>>>>>>>..>>>>..>>..<<<....>>>....>>>
>>>>......>>>>>..>>>
Receptor-Ligand Complex Structure
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PDB8onz Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Resolution2.94 Å
Binding residue
(original residue number in PDB)		K62 K64 K65 K66 N67 K69 K72 H316 R361 N370 R374
Binding residue
(residue number reindexed from 1)		K3 K5 K6 K7 N8 K10 K13 H257 R302 N311 R315
Enzymatic activity
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8onz, PDBe:8onz, PDBj:8onz
PDBsum8onz
PubMed38267453
UniProtG0SEA9

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