Structure of PDB 8ony Chain A Binding Site BS01

Receptor Information
>8ony Chain A (length=371) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKA
LDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKL
IKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHIS
GRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEV
MESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEE
GEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVIN
ENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQ
FEHTILLRPTCKEVVSRGDDY
Ligand information
>8ony Chain 5 (length=156) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaaaagaacuuugaagagagaguucaagagggcguucaaacgagaacu
uugaauuccaugugaacagcaguugaacaugggucucggguucagauccc
cgaaucuuggaaagcgucgcgguuccggcggcguaagggcugguagcagc
cgacuu
..........<<<......>>>..............<<<<<<.......>
>>>>>..<<<<<<...<<.....>>.>>>>>>...<<<<<........>>
>>>..........<<<<<<<.......>>>>>>><<<<<<<<....>>>>
>..>>>
Receptor-Ligand Complex Structure
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PDB8ony Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Resolution2.92 Å
Binding residue
(original residue number in PDB)		E351 H391 V392 I394 R395 N404
Binding residue
(residue number reindexed from 1)		E244 H284 V285 I287 R288 N297
Enzymatic activity
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
GO:0018206 peptidyl-methionine modification
GO:0031365 N-terminal protein amino acid modification
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ony, PDBe:8ony, PDBj:8ony
PDBsum8ony
PubMed38267453
UniProtP50579|MAP2_HUMAN Methionine aminopeptidase 2 (Gene Name=METAP2)

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