Structure of PDB 8om4 Chain A Binding Site BS01

Receptor Information

>8om4 Chain A (length=300) Species: 4932 (Saccharomyces cerevisiae)

TLAELLGRSRIAQVANNHKPLTYTGKKFHPTHQIIETKPSTLYRQEWGLK
SAIPSKIKSRYLVYNDLDTLERITTFEPRGGTQWNRLRFQEMGVPIVSNI
GRQNPFFKYISRPEDESHAKLSLFKEMKGDTDISPAAMKKRLKKITALIR
SFQDEFKEWLVENHPDELKLNSNKLEDYVVKFLNKKLETKTNKKFNTEII
GTGGLSYSLPGKLKNSPNGVIQRTVVPGRILNVVKENNDNKWLAAIGGFV
ADVVFFQSPPSSFNSMGDFIRMKTFLFEILEASMEKNGSVSMHARLLEPQ

Ligand information

>8om4 Chain r (length=1487)

auaagaauaugauguugguucagauuaagcgcuaaauaaggacaugacac
augcgaaucauacguuuauuauugauaagauaauaaauaugugguguaaa
cgugaguaauuuuauuaggaauuaaugaacuauagaauaagcuaaauacu
uaauauauaaaaaggauauauaauauauuuaucuauagucaagccaauaa
ugguuuagguaguagguuuauuaagaguuaaaccuagccaacgauccaua
aucgauaaugaaaguuagaacgaucacguugacucugaaauauagucaau
aucuauaagauacagcagugaggaauauuggacaaugaucgaaagauuga
uccaguuacuuauuaggaugauauauaaauauauauauauaaauugauua
aaaauaaaauccauaaauaauuaaaauaaugauauuaauuaccauauauu
uuuauauggauauauuuuaauaguccugacuaauauuugugccagcaguc
gcgguaacacaaagagggcgagcguuaaucauaaugguuuaaaggauccg
uagaaugaauuauauauuauaauuuagaguuaauaaaauuaauuaaagaa
uuauaauaguaaagaugaaauaaauaauuauaagacuaauauaugugaaa
auauuaauuaaauauuaacugacauugagggauuaaaacuagaguagcga
aacggauucgauacccguguaguucuaguaguaaacuaugaauacaauua
uuuauauauauauauauaaauaauaaaugaaaaugaaaguauuccaccug
aagaguacguuagcaauaaugaaacucaaaacaauagacgguuacagacu
uaagcaguggagcauguuauuuaauucgauaauccacgacuaaccuuacc
auauuuugaauauuauaauaauuaaauuauuauauuacaggcguuacauu
guugucuuuaguucgugcugcaaaguuuuagauuaaguucauaaacgaac
aaaacuccauauauauaauuuuaauuauauauaauuuuauauuauuuauu
aauauaaagaaaggaauuaagacaaaucauaaugauccuuauaauauggg
uaauagacgugcuauaauaaaaugauaauaaaauuauauaaaauauauuu
aauuauauuuaauuaauaauauaaaacauuuuaauuuuuaauauauuuuu
uuauuauauauuaauaugaauuauaaucugaaauucgauuauaugaaaaa
agaauugcuaguaauacguaaauuaguauguuacggugaauauucuaacu
guuucgcacuaaucacucaucacgcguugaaacauauuauuaucuuauua
uuuauauaauauuuuuuaauaaauuuauuaauuuauauuuauuuauauca
gaaauaauaugaauuaaugcgaaguugaaauacaguuaccguaggggaac
cugcggugggcuuauaaauaucuuaaauauucuuaca

....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<
.<<<..<<<..<<<<<<<<<<<<.....>>>>>>>>>>..>>>>>.....
<<<........<<<<<.<<.........<<<<<<<<.<<<<.......>>
>>...........<<<<<<<<.>>>>>>>>.>>>>>>>>....>>>>>>>
<<<....<<<..<<<<<<<<........>>>>>>>>>>>......>>>..
<<<<.<<<<....>>>>...>>>>.>>><<<<<<.........>>>>>><
<<<.....>>>>..>>>>>>.........<<<....<<<<....>>>>..
>>>..>>.>>>>>>.<<<<..<<<<<<........>>>>>>..<<.....
.>>.....>>>>..<<<<<<<<..............>>>>><<<<<<<..
..>>>>>>><<..>>>>>....<<<<<(((.....<<<<.....<<.)))
>>.......>>>>.>>>>>..>>>>>>>>>.....<<<((.....<<<<.
..<.<<.<<<<<<<...>>>>>>>...<<<<<<<<...<<<<<<<<<<..
<<<<<<<...................>>>>>>>..>>.......<<....
>>.>>>>>>>>.>>>>>>>>...>>>...>>>>....<<<<<<...<<..
.<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<
<<<<<<<<<..>>>>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<
<.......<<<<....>>>>.....>>..)))).]<<.<<...<<<<...
..<<<<<<..<<<<<<<<<<......<<........>>..........<<
<<<<<.....<<.<<<<<<<<<<.>>>>>>>>>>.>>.<<<.<<<..<<<
<<<<<<<<..<<<<<<<<<....>>>....<<......>>....>>>>>>
.....<<<.<<<<<<<<........>>>>>>>>..<<<<<<<<<.....>
>>>>>>>>....>>>...>>>>>.>>>...>>>>>>>>>...>>>>>>>.
..>>.>>>>>>>>.....<<<<<<........<<<..<<..<<<<<<...
...>>>>>>..>>....>>>......>>>>>>......<<<<<.<....>
.>>>>>..........<....<<<<<<<........>>>>>>>....>..
...>>>>>>....<<.<<<<<.........>>>>>>>...........>>
>>..>>..>>....<.<<<.<.<<<<<<<<..<<<<<<<<<.<<<...<<
<..<<<.<<<<<...<<<<<<<..>>>>>>>...>>>>>>>>..>>>..>
>>>>>>>>>>>..>>>>>>>>..>.>>>..>.....<<<<<<<<<....>
>>>>>>>>.............................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8om4 METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
• Resolution: 2.32 Å
• Binding residue (original residue number in PDB): T23 P40 S41 Y44 R45 R61 G82 W85 R89 D133 I134 R142 K194 F196
• Binding residue (residue number reindexed from 1): T22 P39 S40 Y43 R44 R60 G81 W84 R88 D132 I133 R141 K193 F195

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0032543 mitochondrial translation
• GO:0070124 mitochondrial translational initiation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8om4, PDBe:8om4, PDBj:8om4
• PDBsum: 8om4
• PubMed: 38199006
• UniProt: Q02950|RT51_YEAST Small ribosomal subunit protein bS1m (Gene Name=MRP51)