Structure of PDB 8oki Chain A Binding Site BS01

Receptor Information
>8oki Chain A (length=901) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKKVIGSIEFGILSPQEIRKMSAVEVTVPDTYDDDGYPIEGGVMDKRMGV
IDPGLRCETCGGRAGECPGHFGHIELARPVIHVGFAKTIYRILESTCREC
GRIKLTDEEIEEYMKKIELARNRRSEFNEIIKEIHKKAKERMVCPHCGAP
QYPIKFEKPTIYWEIRKDEQGNEYRHRLMPTEVRDWLEKIPDKDLPLLGL
DPEKSRPEWMVLTVLPVPPVTARPSITLETGIRAEDDLTHKLVDIIRINN
RLKQNIEAGAPQLIIEDLWDLLQYHVTTYINNEAPGVPPAKHKSGRPLKT
LAQRLKGKEGRFRGNLSGKRVNFSARTVISPDPMISINEVGVPVEVAMEL
TVPEKVTEFNIERLRKMVLNGPDKYPGANYVIDPEGRRRRIMDSNKETLA
NQLDIGWTVERHLMDGDIVLFNRQPSLHRMSIMAHRVRVMPYRTFRLNLA
VCPPYNADFDGDEMNLHVPQTEEAQAEARILMEVQNHIISPRYGGPIIGG
IQDHISGGYLLTREGAYFTRDEVEQMLMFAGVDITELPEPDKYDENGNPL
WSGKTIFSLLLPEDLTVWYRNKLCDEPERCEALEKLIEEKLMPDPEEVRK
LAYDGFVYIQNGKLLSGAIDKKAYGREDGIILDLIVREYGVERARQFLDQ
VTKLTIWVITHKGFTTGIDDEDLPEEARDRIREIIREAEERVNKLIEAYK
RGELEPLPGKSLEDTLESLIMAVLAEARDNAGAVAEKYLGMDNHTVIMAK
TGARGKILNITQMAALLGQQSIRGKRLYRGFRGRVLSHFKPGDLGARAKG
FVVNSYKSGLTPQEYFFHAMGGREGLVDTAVRTAQSGYMQRRLINALQDL
KVEYDGTVRSPEGIIVQFKYGEDGVDPMKSWRGKTVDVDRIIVRTLLKMR
G
Ligand information
Receptor-Ligand Complex Structure
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PDB8oki Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
Resolution3.45 Å
Binding residue
(original residue number in PDB)		K158 L228 K293 K308 R320 Q424 T833
Binding residue
(residue number reindexed from 1)		K158 L228 K293 K308 R320 Q424 T833
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oki, PDBe:8oki, PDBj:8oki
PDBsum8oki
PubMed38709902
UniProtQ8U0M4

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