Structure of PDB 8ok6 Chain A Binding Site BS01

Receptor Information

>8ok6 Chain A (length=368) Species: 5702 (Trypanosoma brucei brucei)

NIGTGDNVLHRAALCGIIELAGKRAKLETALPNFQNELNSILELNMTAAE
PTWLDQFRDKDDRSKPRDLTKQPLPKDTNWADHWTAWAKAALPLLNDETH
QAKLKEYKLAGLQPEKLERARNTIRRLTAEAVAKAQDPTVAESTADLTTE
EDLQKQINQAVYSKDTEPDDDFNGYTAFEGKASTNRQTICGSAVAGSKAT
NAMDALFCVCADDRTNGADAGKACVAGTAPGTGWNPGVTATPTGTMLQKV
RKLCNTHGKTTLSAAAIEGRLTAVGNLLTRGSATSILGSFLATDCSGDQG
SGMCVAYTEVTDAKGTPTKDIPWMQKLDSVRIKLQKHERAVEKLGKPQHD
LKTILTLAKDPAYLQLAS

Ligand information

• Ligand ID: BMA
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
• InChIKey: WQZGKKKJIJFFOK-RWOPYEJCSA-N
• SMILES:
  CACTVS 3.341: OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: beta-D-mannopyranose;
  beta-D-mannose;
  D-mannose;
  mannose
• ZINC: ZINC000003830679
• PDB chain: 8ok6 Chain B Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ok6 A structural classification of the variant surface glycoproteins of the African trypanosomey.
• Resolution: 1.75 Å
• Binding residue (original residue number in PDB): T101 N102 W103
• Binding residue (residue number reindexed from 1): T78 N79 W80
• Annotation score: 4

Gene Ontology

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:8ok6, PDBe:8ok6, PDBj:8ok6
• PDBsum: 8ok6
• PubMed: 37656766
• UniProt: B3GVS7