Structure of PDB 8ojc Chain A Binding Site BS01

Receptor Information
>8ojc Chain A (length=395) Species: 10306 (Human alphaherpesvirus 1 strain KOS) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGPTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCG
GDERDVLRVGSGGFWPRRSRLWGGVDVFHVYDILENVEGTVITLLGLTPE
GHRVAVHVYGTRTFGWYRLKAFGTSSDVEFNCTADNLAIEGGMSDLPAYK
LMCFDIECKAGGEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFS
LGSCDLPESHLNELAARGLPTPVVLEFDSEFEMLLAFMTLVKQYGPEFVT
GYNIINFDWPFLLAKLTDIYKVPLDGYGRMNGRGVFRVWDRSKIKVNGMV
NIDMYGIITDKIKLSSYKLNAVAEAVLKDKKKDLSYRDIPAYYAAGPAQR
GVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINITRTIYDG
Ligand information
Receptor-Ligand Complex Structure
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PDB8ojc Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM
Resolution2.08 Å
Binding residue
(original residue number in PDB)		E370 C371 F381 N466 F470 Y526 Y538 K539 L540 Y557
Binding residue
(residue number reindexed from 1)		E157 C158 F168 N253 F257 Y305 Y317 K318 L319 Y336
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0042025 host cell nucleus
GO:0042575 DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ojc, PDBe:8ojc, PDBj:8ojc
PDBsum8ojc
PubMed38806233
UniProtP04293|DPOL_HHV11 DNA polymerase catalytic subunit (Gene Name=UL30)

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