Structure of PDB 8oeu Chain A Binding Site BS01

Receptor Information
>8oeu Chain A (length=1409) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMD
PRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRC
VCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGGC
GRYQPRIRRSGLELYAEWKHVQEKKILLSPERVHEIFKRISDEECFVLGM
EPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINN
QLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKS
LKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANM
TFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDL
HLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSV
TTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIV
QDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTG
KQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMG
ILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIG
IGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFE
NQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVV
GQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFF
HAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQ
LRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDL
VKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIW
NAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENAT
LLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVG
ALAAQSLGEPATQMKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARD
AERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYISP
WLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDKLVLRIRIM
NKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDG
EFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRK
ALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGP
LMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLD
AEKCKYGME
Ligand information
Receptor-Ligand Complex Structure
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PDB8oeu Structure of transcribing RNA polymerase II-Elongin complex
Resolution3.04 Å
Binding residue
(original residue number in PDB)		Y145 K149 R190 K1132
Binding residue
(residue number reindexed from 1)		Y136 K140 R156 K1082
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oeu, PDBe:8oeu, PDBj:8oeu
PDBsum8oeu
PubMed37932450
UniProtA0A8D1DPV6

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