Structure of PDB 8odu Chain A Binding Site BS01

Receptor Information

>8odu Chain A (length=291) Species: 759272 (Thermochaetoides thermophila DSM 1495)

MEPTLQSILDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLLST
DPAHNLSDAFSQKFGKEARLVEGFDNLYAMEIDPNGSMQDLLGVMQDLAY
AIPGIDEAMSFAEVLKQVNSLSYETIVFDTAPTGHTLRFLQFPTVLEKAL
AKVSQLQTLSDVMEKLDSLRVTISEVNAQFKDERLTTFVCVCIPEFLSLY
ETERMIQELANYGIDTHCIVVNQLLFPKPGSDCEQCTARRRMQKKYLDQI
EELYDEEFNVVKMPLLVEEVRGKERLEKFSEMLIKPFVPPE

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 8odu Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8odu The GET insertase exhibits conformational plasticity and induces membrane thinning.
• Resolution: 5.0 Å
• Binding residue (original residue number in PDB): C281 C284
• Binding residue (residue number reindexed from 1): C233 C236
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.-.-

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
• GO:0045048 protein insertion into ER membrane

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0043529 GET complex

External links

• PDB: RCSB:8odu, PDBe:8odu, PDBj:8odu
• PDBsum: 8odu
• PubMed: 37963916
• UniProt: G0SFE0