Structure of PDB 8lpr Chain A Binding Site BS01

Receptor Information
>8lpr Chain A (length=198) Species: 69 (Lysobacter enzymogenes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANIVGGIEYSINNASLCSVGFSVTRGATKGFVTAGHCGTVNATARIGGAV
VGTFAARVFPGNDRAWVSLTSAQTLLPRVANGSSFVTVRGSTEAAVGAAV
CRSGRTTGYQCGTITAKNVTANYAEGAVRGLTQGNACMGRGDSGGSWITS
AGQAQGVASGGNVQSNGNNCGIPASQRSSLFERLQPILSQYGLSLVTG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8lpr Structural basis for broad specificity in alpha-lytic protease mutants.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		H57 Y171 M192 G192A R192B G193 S195 S214 G215 G216 V217A
Binding residue
(residue number reindexed from 1)		H36 Y123 M138 G139 R140 G141 S143 S159 G160 G161 V163
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 G193 S195 S214
Catalytic site (residue number reindexed from 1) H36 D63 G141 S143 S159
Enzyme Commision number 3.4.21.12: alpha-lytic endopeptidase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8lpr, PDBe:8lpr, PDBj:8lpr
PDBsum8lpr
PubMed1931963
UniProtP00778|PRLA_LYSEN Alpha-lytic protease (Gene Name=alpha-LP)

[Back to BioLiP]