Structure of PDB 8kgr Chain A Binding Site BS01

Receptor Information
>8kgr Chain A (length=780) Species: 10497 (African swine fever virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDVDKYTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSNPSGPSF
DFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQVL
GLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQ
LIIHGFVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSLANHTVK
YYKGLAAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGESELRKR
ELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLD
GMTRARRKILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSI
IKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKT
MFPAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWA
RQLEDILALVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNFKGHLKR
FGQYYYSYGTYVISEQRNIITITELPLRVPTVAYIESIKKSSNRMTFIEE
IIDYSSSETIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLRNCLHSH
LNFVKPKGGIIEFNTYYEILYAWLPYRRELYQKRLMREHAVLKLRIIMET
AIVRYINESAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPEFASIEE
LNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQES
PFPGASVWLEEIDAVEKAIIKGRNTQWKFH
Ligand information
Receptor-Ligand Complex Structure
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PDB8kgr Structure of African swine fever virus topoisomerase II in complex with dsDNA
Resolution3.2 Å
Binding residue
(original residue number in PDB)		M475 N476 K547 R660 Y800 P852 S853 E854 G855 W856 K857 S953 R1004 H1010
Binding residue
(residue number reindexed from 1)		M63 N64 K135 R248 Y388 P440 S441 E442 G443 W444 K445 S541 R592 H598
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8kgr, PDBe:8kgr, PDBj:8kgr
PDBsum8kgr
PubMed38816407
UniProtA0A2X0THW2

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