Structure of PDB 8k1l Chain A Binding Site BS01

Receptor Information
>8k1l Chain A (length=979) Species: 85549 (Artemia salina) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDQHKIPLEELCRRLGTNTETGLTSSQAKSHLEKYGPNALTPPRTTPEWI
KFCKQLFGGFQMLLWIGSILCFIAYTMEKYKNPDVLGDNLYLGLALLFVV
IMTGCFAYYQDHNASKIMDSFKNLMPQFAFVIRDGKKIQLKAEEVTVGDL
VEVKFGDRIPADIRITSCQSMKVDNSSLTGESEPQSRSTECTNDNPLETK
NLAFFFTNTLEGTGRGIVINVGDDSVMGRIACLASSLDSGKTPIAREIEH
FIHIITAMAVSLAAVFAVISFLYGYTWLEAAIFMIGIIVAKVPEGLLATV
TVCLTLTAKRMAKKNCLVRNLEAVETLGSTSTICSDKTGTLTQNRMTVAH
MWFDQKIVTADTTENQSGNQLYRGSKGFPELIRVASLCSRAEFKTEHAHL
PVLKRDVNGDASEAAILKFAEMSTGSVMNIRSKQKKVSEIPFNSANKYQV
SVHEREDKSGYFLVMKGAPERILERCSTILIDGTEIPLDNHMKECFNNAY
MELGGMGERVLGFCDFELPSDQYPRGYVFDADEPNFPISGLRFVGLMSMI
DPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIARQVGIISEGHETVD
DIAARLNIPVSEVNPRSAQAAVIHGNDLKDMNSDQLDDILRHYREIVFAR
TSPQQKLIIVEGVQRQGEFVAVTGDGVNDSPALKKADIGVAMGIAGSDVS
KQAADMILLDDNFASIVTGVEEGRLIFDNIKKSIAYTLTSKIPELSPFLM
YILFDLPLAIGTVTILCIDLGTDVVPAISMAYEGPEADPRKPRDPVKEKL
VNERLISMAYGQIGVMQAFGGFFTYFVIMGECGFLPNRLFGLRKWWESKA
YNDLTDSYGQEWTWDARKQLEYTCHTAFFISIVIVQWTDLIICKTRRLSL
FQQGMKNGTLNFALVFETCVAAFLSYTPGMDKGLRMYPLKIWWWFPPMPF
SLLILVYDECRKFLMRRNPGGFLERETYY
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain8k1l Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8k1l A Na pump with reduced stoichiometry is upregulated by brine shrimp in extreme salinities.
Resolution3.44 Å
Binding residue
(original residue number in PDB)		T196 G197 D353 T355 T592 K673 N695
Binding residue
(residue number reindexed from 1)		T179 G180 D336 T338 T575 K656 N678
Annotation score1
Enzymatic activity
Enzyme Commision number 7.2.2.13: Na(+)/K(+)-exchanging ATPase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8k1l, PDBe:8k1l, PDBj:8k1l
PDBsum8k1l
PubMed38079564
UniProtP17326|AT1A_ARTSF Sodium/potassium-transporting ATPase subunit alpha-A

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