Structure of PDB 8jxg Chain A Binding Site BS01

Receptor Information

>8jxg Chain A (length=1114) Species: 10116 (Rattus norvegicus)

PTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPASHT
CRSNEFQCLSPQRCIPSYWFCDGEADCADGSDEPDTCGHSVNTCRASQFQ
CDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSSTQFTCVNSRPPN
RRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSCANGRCVRQSFRC
DRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFVCDEDNDCGDGSD
EQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDCSDNSDEKGCGIN
ECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSCVDIDECKESPQL
CSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPYLIFSNRYYIRNL
TTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQIIERMFLNKTNRE
TIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRHRKMIAQHCV
DANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIGMDGTNKSVIIST
KIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGSLPHPFA
LTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVYHPYRQ
PIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTVQLRDRTLCMPMC
SSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPHRFCRLGQFQCRD
GNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQCANKRCIPQSWQ
CDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQSWKCDVDNDCGD
YSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDEQ
GCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSDEENCVPRECSES
EFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTSGHCVP
KALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICD
GENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGHQLCNGVDDCGDG
SDEKEEHCRKPTHK

Ligand information

>8jxg Chain M (length=5) Species: 10116 (Rattus norvegicus)

AANAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8jxg Cryo-EM structures elucidate the multiligand receptor nature of megalin.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): R3326 W3342 N3370 H3411 W3427 R3738
• Binding residue (residue number reindexed from 1): R512 W528 N556 H597 W613 R924

External links

• PDB: RCSB:8jxg, PDBe:8jxg, PDBj:8jxg
• PDBsum: 8jxg
• PubMed: 38771880
• UniProt: P98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)