Structure of PDB 8jxd Chain A Binding Site BS01

Receptor Information
>8jxd Chain A (length=493) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKPTHKPCTDTEYKCSNGNCISQHYVCDNVNDCGDLSDETGCNLGDNRTC
AENICEQNCTQLSSGGFICSCRPGFKPSTLDKNSCQDINECEEFGICPQS
CRNSKGSYECFCVDGFKSMSTHYGERCAADGSPPLLLLPENVRIRKYNTS
SEKFSEYLEEEEHIQTIDYDWDPEHIGLSVVYYTVLAQGSQFGAIKRAYI
PNFESGSNNPIREVDLGLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVAT
LDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQGKQPKIESAWMNGEHR
SVLVSENLGWPNGLSIDYLNDDRVYWSDSKEDVIEAIKYDGTDRRLIINE
AMKPFSLDIFEDKLYWVAKEKGEVWRQNKFGKENKEKVLVVNPWLTQVRI
FHQLRYNQSVSNPCKQVCSHLCLLRPGGYSCACPQGSDFVTGSTVQCDAA
SELPVTMPPPCRCMHGGNCYFDENELPKCKCSSGYSGEYCEVG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxd Chain A Residue 4702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxd Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Y3947 D3950 V3952 D3960 E3961
Binding residue
(residue number reindexed from 1)		Y25 D28 V30 D38 E39
Annotation score4
External links
PDB RCSB:8jxd, PDBe:8jxd, PDBj:8jxd
PDBsum8jxd
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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