Structure of PDB 8jxa Chain A Binding Site BS01

Receptor Information

>8jxa Chain A (length=1077) Species: 10116 (Rattus norvegicus)

PTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCG
HSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSS
TQFTCVNSRPPNRRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSC
ANGRCVRQSFRCDRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFV
CDEDNDCGDGSDEQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDC
SDNSDEKGCGINECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSC
VDIDECKESPQLCSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPY
LIFSNRYYIRNLTTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQI
IERMFLNKTNRETIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLE
GRHRKMIAQHCVDANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIG
MDGTNKSVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRH
TVYDGSLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHK
PFDIHVYHPYRQPIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTV
QLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPH
RFCRLGQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQ
CANKRCIPQSWQCDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQ
SWKCDVDNDCGDYSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCN
GFDDCRDNSDEQGCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSD
EENCVPRECSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHP
EHFQCTSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECK
NHVCIQSFWICDGENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGH
QLCNGVDDCGDGSDEKEEHCRKPTHKP

Ligand information

>8jxa Chain M (length=5) Species: 10116 (Rattus norvegicus)

AANAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8jxa Cryo-EM structures elucidate the multiligand receptor nature of megalin.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): R3326 W3342 N3370 H3411
• Binding residue (residue number reindexed from 1): R474 W490 N518 H559

External links

• PDB: RCSB:8jxa, PDBe:8jxa, PDBj:8jxa
• PDBsum: 8jxa
• PubMed: 38771880
• UniProt: P98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)